Take It On The Run

YouTube - REO Speedwagon - Take It On The Run (live)

For a while I thought that take it on the run meant something like "sleep around" (as here), but now I think it just means to "run away" (so Wikipedia). I cannot find the sexual meaning in Google Books, but there are clear instances where it means "run away" or "escape":

• John Dos Passos, The Shackles of Power (1966), 317: "He ran up so many bills that he had to take it on the run, nevertheless, to escape imprisonment for debt; and retired to Sweden."
  
• Clint Willis, Wise Guys (2003), 132: "I was going to have to testify, and I offered two choices: take it on the run, on my own, or let us relocate you and give you a new identity."
  

In other contexts, take it on the run also refers to eating on the go, taking certain things with you, and certain sports and military maneuvers. It also is a line from a famous WWI song, "Over There."